Treatment & Guidelines
Treatment & Guidelines
Durability data from the PARTNER II Trial found aortic valve reintervention was low in patients who had received SAPIEN 3 TAVI at 5 years. Only 1.3% of patients required reintervention versus 0.8% who had received sAVR (odds ratio 0.60 [95% CI, 0.22— 1.65; p=0.31]).1
This evidence of durability at 5 years is further supported by the similar rates of haemodynamic valve deterioration (HVD) and bioprosthetic valve failure (BVF). 1
Rate of HVD and BVF at 5 years 1
In a long-term, real-world follow up study (n=235║), 93.5% of patients who had a TAVI were free from structural valve deterioration (SVD) and BVF at 10 years and only 2 required reintervention.2
What could long-term durability with TAVI mean for your severe AS patients?
Manufactured using the same tissue processing as the Perimount Magna Ease, the SAPIEN 3 valve was built on the proven SAPIEN platform and designed with patient needs in mind. More information can be accessed on the Edwards website.4
*Data from the PARTNER II Trial of TAVI in intermediate-risk severe aortic stenosis patients.1
†Violin plots have become the new standard for representing echocardiographic data. Like box plots they show the distribution of the data, with the addition of the density of the data at different values.5
‡Stage 2 & 3 HVD defined as: + Δ mean gradient ≥ 10 mmHg and -Δ AVA ≥ 0.3 cm² or ≥ 25%, -Δ DVI ≥ 0.1 or ≥ 20%, AND/OR ≥ 1 grade Δ transvalvular AR with final grade ≥ moderate.
$Bioprothetic valve failure defined as: Reintervention or death related to valve dysfunction, or severe (Stage 3) structural valve deterioration-related HVD.1
║77.4% of patients in the follow-up study had received Edwards SAPIEN.²
Kodali SK, et al. Presentation at the Transcatheter Valve Therapies (TVT) Summit virtual event: TVT Connect 2020.
Available at: https://www.tctmd.com/slide/sapien-3-transcatheter-aortic-valve-replacement-compared-surgery-intermediate-risk-patients (accessed March 2021).
Carron J. Violin Plots 101: Visualizing Distribution and Probability Density.
Available at: https://mode.com/blog/violin-plot-examples (accessed April 2021)
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